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This research aims to create a mathematical framework for understanding human physiological processes through feedback mechanisms.

July 30, 2026Open Access

A Structural Loop‑Model Analysis of Human Physiological Regulation: Thermoregulation, Labour and Glucose Homeostasis

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This research aims to create a mathematical framework for understanding human physiological processes through feedback mechanisms.
Introduced an extended mathematical framework for homeostatic feedback using differential state-space equations.
Refined loop definitions for physiological processes such as thermoregulation and glucose regulation.
Integrated a dual-effector control model for pancreatic regulation involving alpha and beta cells.
Established a unified model linking negative feedback (thermoregulation, glucose control) and positive feedback (oxytocin-driven labour).
Provided explicit modeling of delay vectors for physiological responses and time transport.
Updated definitions and system-mapping tables enhance understanding of homeostatic balance and threshold dynamics.

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Randomized trial investigates dynamic control of thermoregulation and glucose stability, highlighting feedback mechanisms.

Matthew Arthur Carlo (2026) studied this question.

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