Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy

Figures

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  Figure 1. Experimental assembly of the pressurization test. (a) Thoracic aorta without stretching and free of loads, immersed in Krebs; (b) Pressurization of a previously stretched thoracic aortic artery.

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  Figure 2. Representation of arterial wall with two embedded families of fibres. The mean orientations of the collagen fibres are characterized by the angle \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\gamma$$\end{document}γ.

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  Figure 3. (a) Representation 2D of the boundary conditions for the computational simulation of the pressurization test. (b) View of the 2D finite element mesh.

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  Figure 4. Algorithm of the inverse problem-solving method. The evolutionary loop shows the main steps of the optimization problem.

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  Figure 5. (a,b) Thoracic aorta characterization via Cauchy stress-stretch curves for control (CN) and melatonin (MN) group lambs. The fitting were compute via GHO’s model. (c,d) Realistic numerical results of the GHO model tensile stretchs for the aorta artery. (e,f) FEM numerical simulation of the pressurization test.