Key result
Exposure to hypoxia for 21 days significantly reduced the normalized distensibility of pulmonary arteries in rats compared with normoxia (0.015 vs 0.025 mmHg(-1); P<0.001).
Why the study?
Does hypoxia-induced arterial remodeling alter pulmonary arterial morphometry and distensibility in Sprague-Dawley rats?
Population
Sprague-Dawley rats (n=18)
Comparison
Hypoxia (10% O2) exposure for 21 days vs Normoxia (21.0% O2) exposure for 21 days
Design
Preclinical
Follow-up
21 days
Authors
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Hypoxia-induced pulmonary vascular changes in rats should not alter clinical practice; hypothesis-generating for remodeling mechanisms in pulmonary hypertension.
Does hypoxia-induced arterial remodeling alter pulmonary arterial morphometry and distensibility in Sprague-Dawley rats?
Absolute Event Rate: 0.015% vs 0.025%
p-value: p=< 0.001
Volumetric micro-computed tomography can quantitatively differentiate structural and biomechanical changes, such as reduced arterial distensibility, in hypoxia-induced pulmonary arterial remodeling.
Molthen et al. (2004) studied Hypoxia-induced arterial remodeling (n=18). Hypoxia (10% O2) vs. Normoxia (21.0% O2) was evaluated on Normalized distensibility of the arteries (p=< 0.001). Exposure to hypoxia for 21 days significantly reduced the normalized distensibility of pulmonary arteries in rats compared with normoxia (0.015 vs 0.025 mmHg(-1); P<0.001).
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