Key result
Increased epicardial fat tissue thickness is significantly correlated with increased transmural dispersion of repolarisation parameters, including the Tp-Te interval (r=0.564), though this relationship was not independent in multivariate analysis.
Why the study?
Epicardial fat releases proinflammatory and atherogenic mediators that affect the heart, but the relationship between epicardial fat tissue thickness and transmural dispersion of repolarisation in healthy individuals needed evaluation.
Does increased epicardial fat tissue thickness correlate with increased transmural dispersion of repolarisation (Tp-Te, Tp-Te(d), Tp-Te/QT ratio) in healthy individuals?
Cross-Sectional (n=1,713)
No
Does increased epicardial fat tissue thickness correlate with increased transmural dispersion of repolarisation (Tp-Te, Tp-Te(d), Tp-Te/QT ratio) in healthy individuals?
Effect estimate: r = 0.564
p-value: p=<0.0001
While epicardial fat tissue thickness correlates with ventricular repolarization parameters in healthy individuals, it is not an independent predictor when adjusting for age, BMI, and left ventricular mass.
Epicardial fat thickness associates with repolarization dispersion yet not independently after adjustment; leaves open its role beyond age, BMI, and LV mass.
INTRODUCTION: Epicardial fat is a tissue that releases many proinflammatory and atherogenic mediators, with endocrine and paracrine effects on the heart. In this study, the implication of the EFT thickness (EFTt) on transmural dispersion of repolarisation (TDR) was analysed utilizing the T-wave peak to end interval (Tp-Te), the Tp-Te dispersion (Tp-Te (d)), and the Tp-Te/QT ratio. MATERIAL AND METHODS: One thousand seven hundred and thirteen subjects were enrolled in the research. The subjects were chosen to be healthy individuals, without any cardiovascular/systemic disorders or risk factors for atherosclerosis. Transthoracic echocardiography (TTE) was applied to all subjects, and EFTt was measured in both diastole and systole. The ECG measurements were taken from standard 12-lead surface ECG. RESULTS: Correlation analysis revealed that the EFTt is highly associated with the Tp-Te interval, Tp-Te/QT ratio, Tp-Te (d), increasing age, body mass index (BMI), body surface area (BSA), left ventricular (LV) mass, LV mass index, plasma glucose during fasting, triglycerides, and low-density lipoprotein cholesterol. CONCLUSIONS: The study results showed that increased EFTt was associated with increased TDR values of Tp-Te, Tp-Te (d), and Tp-Te/QT ratio, even in the absence of other factors that could increase TDR and EFTt. Therefore, it can be stated that increased EFTt may cause an increase the risk for ventricular arrhythmia.
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Yılmaz et al. (2020) conducted a cross-sectional in Healthy individuals (n=1,713). Epicardial fat tissue thickness was evaluated on Correlation between epicardial fat tissue thickness in diastole and Tp-Te interval (r = 0.564, p=<0.0001). Increased epicardial fat tissue thickness is significantly correlated with increased transmural dispersion of repolarisation parameters, including the Tp-Te interval (r=0.564), though this relationship was not independent in multivariate analysis.
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