Key result
Increased epicardial fat tissue thickness (≥ 9 mm) was significantly associated with prolonged Tp-e intervals and higher Tp-e/QT ratios, suggesting an increased risk of ventricular arrhythmia.
Cross-Sectional (n=90)
Absolute Event Rate: 83.1% vs 76%
p-value: p=<0.001
Increased epicardial fat tissue thickness is significantly associated with prolonged ventricular repolarization parameters, suggesting a potential structural mechanism for increased ventricular arrhythmia risk.
Supports potential link between epicardial fat and repolarization abnormalities; hypothesis-generating, requiring prospective validation before clinical consideration.
BACKGROUND: The association between periatrial adiposity and atrial arrhythmias has been shown in previous studies. However, there are not enough available data on the association between epicardial fat tissue (EFT) thickness and parameters of ventricular repolarization. Thus, we aimed to evaluate the association of EFT thickness with indices of ventricular repolarization by using T-peak to T-end (Tp-e) interval and Tp-e/QT ratio. METHODS: The present study included 50 patients whose EFT thickness ≥ 9 mm (group 1) and 40 control subjects with EFT thickness < 9 mm (group 2). Transthoracic echocardiographic examination was performed in all participants. QT parameters, Tp-e intervals and Tp-e/QT ratio were measured from the 12-lead electrocardiogram. RESULTS: QTd (41.1 ± 2.5 vs 38.6 ± 3.2, p < 0.001) and corrected QTd (46.7 ± 4.7 vs 43.7 ± 4, p = 0.002) were significantly higher in group 1 when compared to group 2. The Tp-e interval (76.5 ± 6.3, 70.3 ± 6.8, p < 0.001), cTp-e interval (83.1 ± 4.3 vs. 76±4.9, p < 0.001), Tp-e/QT (0.20 ± 0.02 vs. 0.2 ± 0.02, p < 0.001) and Tp-e/QTc ratios (0.2 ± 0.01 vs. 0.18 ± 0.01, p < 0.001) were increased in group 1 in comparison to group 2. Significant positive correlations were found between EFT thickness and Tp-e interval (r = 0.548, p < 0.001), cTp-e interval (r = 0.259, p = 0.01), and Tp-e/QT (r = 0.662, p < 0.001) and Tp-e/QTc ratios (r = 0.560, p < 0.001). CONCLUSION: The present study shows that Tp-e and cTp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in subjects with increased EFT, which may suggest an increased risk of ventricular arrhythmia.
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Kaplan et al. (2015) conducted a cross-sectional in Increased epicardial fat tissue thickness (n=90). Increased epicardial fat tissue thickness (≥ 9 mm) vs. Epicardial fat tissue thickness < 9 mm was evaluated on Tp-e interval (p=<0.001). Increased epicardial fat tissue thickness (≥ 9 mm) was significantly associated with prolonged Tp-e intervals and higher Tp-e/QT ratios, suggesting an increased risk of ventricular arrhythmia.
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