FTO gene single-nucleotide polymorphisms rs9939609, rs1421085, and rs17817449 were significantly associated with obesity, particularly class III obesity, in the Mexican population (P=0.0000004).
Observational (n=788)
Are FTO gene polymorphisms associated with adulthood obesity in the Mexican population?
FTO gene polymorphisms are a major risk factor for class III obesity in the Mexican-Mestizo population and are associated with upregulated FTO expression in subcutaneous fat tissue.
p-value: p=0.0000004
Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican-Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single-nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models (P = 0.0000004 and 0.000008, respectively). These associations remained significant after adjusting for admixture (P = 0.000003 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B-cell function (HOMA-B), and with higher homeostasis model assessment of insulin sensitivity (HOMA-S) only in nonobese individuals (P (dom) = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese individuals than in lean individuals (P = 0.043). Risk alleles were significantly associated with higher FTO expression in the class III obesity group (P = 0.047). In conclusion, FTO is a major risk factor for obesity (particularly class III) in the Mexican-Mestizo population, and is upregulated in subcutaneous fat tissue of obese individuals.
Villalobos‐Comparán et al. (2008) conducted an observational in Obesity (n=788). FTO gene polymorphisms (rs9939609, rs1421085, rs17817449) vs. Absence of risk alleles was evaluated on Obesity (particularly class III) (p=0.0000004). FTO gene single-nucleotide polymorphisms rs9939609, rs1421085, and rs17817449 were significantly associated with obesity, particularly class III obesity, in the Mexican population (P=0.0000004).