Key result
Angiotensin II binding sites were demonstrated in human mononuclear leucocytes, showing rapid, reversible binding with affinity constants comparable to other main target tissues.
This study provides basic science evidence for the presence of specific Angiotensin II binding sites on human mononuclear leucocytes.
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No immediate clinical implications; leaves open functional roles of Ang II receptors on leukocytes pending mechanistic studies.
Shimada et al. (1978) studied this question. [125I]angiotensin II vs. unlabeled compounds was evaluated on Binding characteristics of [125I]angiotensin II to mononuclear leucocytes. Angiotensin II binding sites were demonstrated in human mononuclear leucocytes, showing rapid, reversible binding with affinity constants comparable to other main target tissues.
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