Key result
Patients with central serous chorioretinopathy had significantly higher log LF/HF values (0.34 vs 0.22, P < 0.001) compared to controls, indicating impaired autonomic nervous system function.
Why the study?
The study was conducted to quantitatively analyze heart rate variability in patients with central serous chorioretinopathy using a smartphone application and clarify its relationships with the condition.
Does heart rate variability analysis using a smartphone application show autonomic impairment in patients with central serous chorioretinopathy compared to controls?
Case-Control (n=35,290)
No
Does heart rate variability analysis using a smartphone application show autonomic impairment in patients with central serous chorioretinopathy compared to controls?
May link autonomic dysfunction to central serous chorioretinopathy; hypothesis-generating and requires prospective validation before clinical use.
The purpose of this study was to quantitatively analyze heart rate variability (HRV) in patients with central serous chorioretinopathy (CSC) by using a smartphone-based application (ANBAI: DUMSCO Inc.) for measurement, and to clarify its relationships with CSC. The subjects were 64 CSC patients (mean age 48.7 ± 7.6 years, 57 males and 7 females). After providing consent, the patients downloaded ANBAI apps to their smartphones. HRV was measured by photoelectric volume pulse wave measurement with a smartphone camera each morning for a minimum of 1 week. The primary outcome was to analyze HRV by calculating log LF/HF (Low Frequency/High Frequency components), an index of autonomic tone, which was then compared with a control group of 35,226 individuals from the application. Secondary outcome measures included disease duration, body mass index, exercise habits, smoking history, steroid use, occupation, lifestyle regularity, psychological fatigue, physical fatigue, and average sleep time. The log LF/HF was significantly higher in the patient group than in the control group (P < 0.001). Log LF/HF was significantly lower in patients with exercise habits as a factor contributing to log LF/HF in the patient group (P = 0.019). Analysis of HRV in CSC patients showed an impairment of the autonomic nervous system. Exercise habits may also be associated with CSC.
No takes yet. Share an insight, caveat, or question.
Takeshima et al. (2020) conducted a case-control in Central serous chorioretinopathy (n=35,290). Central serous chorioretinopathy vs. Controls (general application users) was evaluated on log LF/HF (Low Frequency/High Frequency components) as an index of autonomic tone (p=<0.001). Patients with central serous chorioretinopathy had significantly higher log LF/HF values (0.34 vs 0.22, P < 0.001) compared to controls, indicating impaired autonomic nervous system function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: