Key result
Patients with primary Sjogren's syndrome exhibited significantly greater muscle sympathetic nerve activity at rest compared to healthy controls (30.57 vs 20.71 bursts/min, p=0.038).
Why the study?
Reports on autonomic dysfunction in primary Sjögren's syndrome are conflicting, and data on the functional status of sympathetic outflow to vessels and baroreceptor control mechanisms were lacking.
Does primary Sjogren's syndrome alter cardiovascular autonomic profile and baroreceptor modulation compared to healthy controls?
Case-Control (n=33)
Yes
Does primary Sjogren's syndrome alter cardiovascular autonomic profile and baroreceptor modulation compared to healthy controls?
Absolute Event Rate: 30.57% vs 20.71%
p-value: p=0.038
Patients with primary Sjogren's syndrome exhibit lower cardiac baroreflex control, greater parasympathetic modulation at rest, and enhanced sympathetic nerve activity both supine and during orthostatic challenge compared to healthy controls.
Highlights autonomic imbalance in primary Sjögren's syndrome; hypothesis-generating for cardiovascular risk assessment.
Primary Sjögren's syndrome (pSS) is an autoimmune disease affecting exocrine glands and extra-glandular organs. There are conflicting reports on the presence of autonomic dysfunction in pSS and no data are available on the functional status of sympathetic outflow to the vessels and baroreceptor (BRS) control mechanisms. We investigated the cardiac (cBRS) and sympathetic (sBRS) baroreceptor modulation in both time and frequency domains and the cardiovascular autonomic profile in pSS patients compared to healthy controls. Autonomic symptoms were quantified by the COMPASS31 3-item questionnaire. The ESSPRI questionnaire evaluated the magnitude of pSS clinical symptoms, i.e. fatigue, pain and sicca symptoms. ECG, beat-by-beat arterial pressure and respiratory activity were continuously recorded in 17 pSS patients and 16 healthy controls, while supine and during 75° head-up tilt. In 7 patients and 7 controls, muscle sympathetic nerve activity (MSNA) was measured. Spectrum analysis of RR variability provided markers of cardiac vagal modulation (HFRR n.u.) and sympatho-vagal balance (LF/HF). The power of low frequency (LF,0.1Hz) oscillations of systolic arterial pressure (SAP) variability (LFSAP) evaluated the vasomotor response to sympathetic stimulation. Compared to controls, pSS patients scored higher in total COMPASS31 (p<0.0001) and all ESSPRI subdomains (fatigue, p=0.005; pain, p=0.0057; dryness, p<0.0001). Abnormal scialometry (<1.5 ml/15 min) and Shirmer tests (< 5 mm/5 min) were found in pSS patients and salivary flow rate was negatively associated with ESSPRI dryness (p=0.0014). While supine, pSS patients had lower SEQcBRS index of cardiac baroreceptor sensitivity, higher HFRR nu (p=0.021), lower LF/HF (p=0.007) and greater MSNA (p=0.038) than controls. No differences were observed in LFSAP between groups. During orthostatic challenge, although LFSAP increased similarly in both groups, MSNA was greater in pSS patients (p=0.003). At rest pSS patients showed lower cardiac baroreflex control and greater parasympathetic modulation. Furthermore, greater sympathetic nerve activity was observed in pSS patients while supine and in response to gravitational challenge. We hypothesized that such enhanced sympathetic vasoconstrictor activity might reflect an attempt to maintain blood pressure in a setting of likely reduced vascular responsiveness.
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Brunetta et al. (2019) conducted a case-control in Primary Sjogren's Syndrome (n=33). Primary Sjogren's syndrome vs. Healthy controls was evaluated on Muscle sympathetic nerve activity (MSNA) at rest (bursts/min) (p=0.038). Patients with primary Sjogren's syndrome exhibited significantly greater muscle sympathetic nerve activity at rest compared to healthy controls (30.57 vs 20.71 bursts/min, p=0.038).
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