What question did this study set out to answer?

To quantify the risk of developing hyperglycemia that requires the initiation of hypoglycemic therapy in patients receiving oral glucocorticoids.

January 10, 1994Archives of Internal Medicine

Glucocorticoids and the Risk for Initiation of Hypoglycemic Therapy

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To quantify the risk of developing hyperglycemia that requires the initiation of hypoglycemic therapy in patients receiving oral glucocorticoids.
Conducted a population-based case-control study using the New Jersey Medicaid database among enrollees aged 35 years or older between 1981 and 1990.
Identified 11,855 case patients who newly initiated hypoglycemic therapy (oral medication or insulin) and 11,855 randomly selected Medicaid controls.
Estimated relative risk and odds ratios adjusted for demographic characteristics, health service utilization, and concomitant medications.
Oral glucocorticoid users had an increased risk of developing hyperglycemia requiring therapy compared with nonusers (estimated relative risk 2.23; 95% CI, 1.92 to 2.59).
Risk rose markedly with higher average daily doses in hydrocortisone-equivalent milligrams: OR 1.77 for 1 to 39 mg/d, OR 3.02 for 40 to 79 mg/d, OR 5.82 for 80 to 119 mg/d, and OR 10.34 for 120 mg/d or more.

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Implication

Case-control study demonstrates increased hypoglycemic therapy initiation in oral glucocorticoid users, indicating strong dose-dependent hyperglycemia risk.

Cite This Study

Jerry H. Gurwitz (1994) studied this question.

synapsesocial.com/papers/6a1ff6bec1b320180d0db471 https://doi.org/10.1001/archinte.1994.00420010131015

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Implication

Case-control study demonstrates increased hypoglycemic therapy initiation in oral glucocorticoid users, indicating strong dose-dependent hyperglycemia risk.

Glucocorticoids and the Risk for Initiation of Hypoglycemic Therapy

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Discussion

Implication

Cite This Study

Glucocorticoids and the Risk for Initiation of Hypoglycemic Therapy

Key Points

Discussion

Implication

Cite This Study

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