What question did this study set out to answer?

To examine whether enterically released rapamycin extends lifespan and limits tumor progression in Rb1+/− mice, a neuroendocrine cancer model unresponsive to dietary restriction.

February 23, 2013AgingOpen Access

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

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Authors

CLCarolina B. LiviSouthern Oregon University RHRulon L. HardmanAdvanced Imaging Research (United States)BCBarbara A. ChristyThe University of Texas Health Science Center at San Antonio

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Implication

Preclinical study demonstrates that rapamycin significantly extends lifespan and suppresses neuroendocrine tumors in Rb1+/− mice, suggesting mechanisms distinct from dietary restriction.

Key Points

To examine whether enterically released rapamycin extends lifespan and limits tumor progression in Rb1+/− mice, a neuroendocrine cancer model unresponsive to dietary restriction.
Fed male and female Rb1+/− mice a control diet or diet supplemented with enterically released rapamycin (eRapa at 14 mg/kg food, ~2.24 mg/kg/day, achieving ~4 ng/ml blood levels) starting at 9 weeks of age until death.
Tracked overall survival duration and assessed the incidence and progression of pituitary and thyroid neuroendocrine tumors.
eRapa significantly increased the median and maximum lifespan in both male and female Rb1+/− mice.
Rapamycin treatment slowed the development and growth of pituitary tumors and reduced thyroid tumor incidence.
The survival and anti-tumor benefits of rapamycin operated independently of Rb1 gene dosage, unlike dietary restriction.

Cite This Study

Livi et al. (2013) studied this question.

synapsesocial.com/papers/6a1ff7518fbc0747110dae89 https://doi.org/10.18632/aging.100533

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Implication

Preclinical study demonstrates that rapamycin significantly extends lifespan and suppresses neuroendocrine tumors in Rb1+/− mice, suggesting mechanisms distinct from dietary restriction.

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

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