Key result
Oral propranolol treatment successfully improved the QTc interval from 544 ms to 485 ms and prevented further episodes of bradycardia and desaturation in a two-month-old infant with congenital long QT syndrome.
Why the study?
Diagnosing congenital long QT syndrome in infancy can be challenging due to overlapping presentations with common pediatric illnesses, highlighting the need to increase physician awareness.
Case Report (n=1)
Congenital Long QT Syndrome in infancy can present atypically with desaturation and bradycardia mimicking common respiratory illnesses, highlighting the importance of ECG screening in cases with suspicious family history or unexplained events.
Long QT syndrome (LQTS), is an arrhythmia disorder, related to ventricular myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram that can lead to symptomatic ventricular arrhythmias and increase the mortality rate. The prevalence of congenital LQTS is about 1 in 2000 live births. Here, we report the case of a two-month-old female, with a significant family history of early death, who was brought to our emergency with an episode of blueish discoloration. The initial workup was positive for COVID-19 in the respiratory panel, so she was admitted as a case of bronchiolitis. It was a challenge because of the overlapping presentation between a serious condition and other common pediatric illnesses. Furthermore, the paper aims to increase awareness of this condition among physicians and emphasizes the importance of obtaining a complete medical history, physical examination, and family screening in selected cases to facilitate early diagnosis and timely management.
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Aldirawi et al. (2024) conducted a case report in Congenital Long QT Syndrome (LQTS) (n=1). Propranolol was evaluated on QTc interval. Oral propranolol treatment successfully improved the QTc interval from 544 ms to 485 ms and prevented further episodes of bradycardia and desaturation in a two-month-old infant with congenital long QT syndrome.
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