What question did this study set out to answer?

To directly quantify the distinct metabolic sources—circulating nonesterified fatty acids, dietary fat, and de novo lipogenesis—contributing to hepatic and plasma lipoprotein triacylglycerols in patients with nonalcoholic fatty liver disease.

May 2, 2005Journal of Clinical InvestigationOpen Access

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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Authors

KDKerry L. DonnellyUniversity of Minnesota CSColeman I. SmithGeorgetown University SSSarah Jane SchwarzenbergUniversity of Minnesota

Discussion

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Implication

Metabolic tracer study reveals that circulating free fatty acids and de novo lipogenesis drive liver fat accumulation in NAFLD, suggesting multiple pathways contribute to steatosis.

Key Points

To directly quantify the distinct metabolic sources—circulating nonesterified fatty acids, dietary fat, and de novo lipogenesis—contributing to hepatic and plasma lipoprotein triacylglycerols in patients with nonalcoholic fatty liver disease.
Administered intravenous and oral stable isotope tracers over 4 days to 9 obese patients (5 male, 4 female; age 44 ± 10 years) scheduled for a diagnostic liver biopsy.
Tracked and quantified fatty acid origins in liver tissue and lipoprotein triacylglycerols using gas chromatography/mass spectrometry.
Hepatic triacylglycerol accounted for in the liver originated 59.0% ± 9.9% from serum nonesterified fatty acids, 26.1% ± 6.7% from de novo lipogenesis, and 14.9% ± 7.0% from dietary sources.
Very low-density lipoprotein triacylglycerol labeling closely mirrored liver tissue, displaying reciprocal hepatic use of adipose-derived and dietary fatty acids over the 4-day period.
De novo lipogenesis was elevated in the fasting state and lacked normal diurnal variation throughout the tracking period.

Cite This Study

Donnelly et al. (2005) studied this question.

synapsesocial.com/papers/6a1ff9763224f8dacd0db564 https://doi.org/10.1172/jci200523621

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Implication

Metabolic tracer study reveals that circulating free fatty acids and de novo lipogenesis drive liver fat accumulation in NAFLD, suggesting multiple pathways contribute to steatosis.

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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