Key result
An increased epicardial adipose tissue volume (≥50 cm3/m2) was the strongest independent determinant of the presence of coronary total occlusions (OR 4.64).
Why the study?
Is increased epicardial fat volume measured by MDCT associated with the severity of coronary atherosclerosis and total occlusions in patients with stable effort angina?
Cross-Sectional (n=71)
No
Is increased epicardial fat volume measured by MDCT associated with the severity of coronary atherosclerosis and total occlusions in patients with stable effort angina?
Odds Ratio: 4.64 (95% CI 1.21–17.72)
p-value: p=0.02
Increased epicardial fat volume quantified by MDCT is strongly associated with coronary atheromatosis and totally occlusive lesions, suggesting it may serve as a non-invasive marker for advanced coronary artery disease.
Supports epicardial fat volume as a marker of severe CAD on MDCT; hypothesis-generating and should not yet change practice.
BACKGROUND: The relationship between the epicardial fat volume measured by 64-slice multidetector computed tomography (MDCT) and the extension and severity of coronary atherosclerosis was investigated. METHODS AND RESULTS: Both MDCT and conventional coronary angiography (CAG) were performed in 71 consecutive patients who presented with effort angina. The volume of epicardial adipose tissue (EAT) was measured by MDCT. The severity of coronary atherosclerosis was assessed by evaluating the extension of coronary plaques in 790 segments using MDCT data, and the percentage diameter stenosis in 995 segments using CAG data. The estimated volume of EAT indexed by body surface area was defined as VEAT. Increased VEAT was associated with advanced age, male sex, degree of metabolic alterations, a history of acute coronary syndrome (ACS) and the presence of total occlusions, and showed positive correlation with the stenosis score (r=0.28, P=0.02) and the atheromatosis score (r=0.67, P<0.0001) of the coronary arteries. Multiple logistic regression analysis revealed an increased VEAT (>or=50 cm(3)/m(2)) to be the strongest independent determinant of the presence of total occlusions (odds ratio 4.64, P=0.02). CONCLUSIONS: VEAT correlates with the degree of metabolic alterations and coronary atheromatosis. Excessive accumulation of EAT might contribute to the development of ACS and coronary total occlusions.
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Ueno et al. (2009) conducted a cross-sectional in Stable effort angina and coronary atherosclerosis (n=71). Increased epicardial adipose tissue volume (VEAT ≥50 cm3/m2) vs. VEAT <50 cm3/m2 was evaluated on Presence of total occlusions of coronary arteries (OR 4.64, 95% CI 1.21-17.72, p=0.02). An increased epicardial adipose tissue volume (≥50 cm3/m2) was the strongest independent determinant of the presence of coronary total occlusions (OR 4.64).
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