Key result
A positive family history of sudden cardiac death was associated with a 12-fold, 8.7-fold, and 7-fold higher likelihood of a family history of CAD, diabetes, and hypertension, respectively.
Why the study?
Does screening for family history of sudden cardiac death identify individuals at high risk for coronary artery disease and related risk factors in the general population?
Cross-Sectional (n=8,786)
Does screening for family history of sudden cardiac death identify individuals at high risk for coronary artery disease and related risk factors in the general population?
Screening for a family history of sudden cardiac death in the general population effectively identifies individuals with a significantly higher burden of cardiovascular risk factors, highlighting its value as a red flag for familial evaluation.
Answers are grounded in this paper and cite their sources.
SCD family history signals elevated familial cardiovascular risks; leaves open whether screening enhances risk identification in the general population.
As there are no large scale Egyptian surveys estimating the prevalence of cardiac disease and the incidence of SCD in a non-selected population, the purpose of this report was to assess the relation between family history of SCD and the presence of CAD or coronary risk factors in first degree relatives of SCD victims searching for potential victims. A questionnaire screening CAD risk factors and cardiac problems as indicators for SCD was developed, Data were collected from 8786 candidates by means of a questionnaire only protocol (random samples (8117)) and questionnaire plus clinical examination, ECG and laboratory investigations during medical convoys (random samples (669)). Data were coded and verified according to presence and absence of CAD risk factors, IHD and other risk factors in order that a triage could be performed in the general population to detect adults at risk of SCD. Family history of CAD, DM and HTN head the list of risk factors more frequently associated with family history of SCD clearly pointing the role played by those comorbidities in pointing to potential victims of SCD. Compared to those with no family history of SCD, those with positive family history of SCD were 8.7 times more associated with family history of DM, 12 times more associated with family history of CAD, 7 times more associated with family history of HTN. This study underscores the importance of searching for positive family history of sudden cardiac death as a warning marker a red flag that makes familial evaluation strongly recommended.
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Hamid et al. (2018) conducted a cross-sectional in Sudden cardiac death risk (n=8,786). Positive family history of sudden cardiac death vs. No family history of sudden cardiac death was evaluated on Family history of CAD (OR 12). A positive family history of sudden cardiac death was associated with a 12-fold, 8.7-fold, and 7-fold higher likelihood of a family history of CAD, diabetes, and hypertension, respectively.
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