Key result
Screening first-degree family members of patients with suspected coronary artery disease revealed that 60% had a >1% risk of developing CAD in the next 10 years.
Why the study?
A positive family history of CAD provides an opportunity to intervene on modifiable risk factors, but risk factor prevalence and estimated 10-year CAD risk in these family members required assessment.
What is the prevalence of cardiovascular risk factors and the estimated 10-year CAD risk among family members of patients with suspected CAD?
Cross-Sectional (n=60)
No
What is the prevalence of cardiovascular risk factors and the estimated 10-year CAD risk among family members of patients with suspected CAD?
Screening family members of patients with suspected CAD reveals a high burden of modifiable risk factors, highlighting a critical window for secondary prevention.
Supports family screening for CAD risk; leaves open whether early intervention improves outcomes in relatives.
BACKGROUND: Early diagnosis of asymptomatic coronary artery disease (CAD) is presently targeted in preventive cardiology. A positive family history though not modifiable can provide a window of opportunity for intervening on modifiable risk factors. We assessed the prevalence of risk factors among the family members of suspected CAD patients and estimated their 10 years CAD risk. METHODS: In a hospital-based cross-sectional study, socio-demographic, personal data and blood samples for total and HDL cholesterol were collected. The risk of having a heart attack in the next 10 years was calculated using Framingham Risk Score. RESULTS: The mean age of participants (n = 60) was 40.55 ± 1.78 years. 85% were physically inactive. Smoking (13%), alcohol use (12%), history of CAD (2%), HTN (12%) and diabetes (22%) were the observed risk factors. A family history of CAD at <40 years of age was reported by 7% of subjects. Prevalence of overweight was 21% and 11% were obese. Increased waist-hip ratio (43%), diabetes (22%), hypercholesterolemia (28%), reduced HDL Cholesterol (48%) were other prevalent risk factors. Risk of CAD of >1% in the next 10 years was noted among 60% of subjects. CONCLUSIONS: Window of opportunity for secondary prevention exists among the family members of suspected CAD.
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Gupta et al. (2019) conducted a cross-sectional in First-degree family members of suspected coronary artery disease patients (n=60). Family history of suspected coronary artery disease was evaluated on 10-year risk of coronary artery disease >1% (Framingham Risk Score). Screening first-degree family members of patients with suspected coronary artery disease revealed that 60% had a >1% risk of developing CAD in the next 10 years.
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