Key result
Smoking was an independent predictor of premature coronary artery disease in adults aged 45 years or younger, increasing the risk with an odds ratio of 2.30.
Why the study?
The study was conducted to assess the frequency and risk factors of coronary artery disease in young patients.
Observational (n=862)
No
Effect estimate: OR 2.30 (95% CI 1.6-3.2)
p-value: p=<0.001
Smoking and male gender are the strongest independent predictors of premature coronary artery disease in adults aged 45 years or younger.
May warrant targeted smoking cessation in adults ≤45 years; extends observational data on premature CAD predictors but requires prospective validation.
Purpose: The purpose of this study was to assess frequency, risk factors of young patients with coronary artery disease (CAD).Materials and Methods: Medical recordings of 21514 patients who underwent coronary angiography were screened for this study between January 2000 and March 2016. Patients older than 45 years old and severe valvular disease were excluded study. A total 862 patients ıncluded study. Major risk factors for CAD were identified. Results: Out of total 862 patients studied, 595 had CAD and 267 had normal coronary arteries (NCA). The young CAD group had a significantly higher proportion of males (94.1 vs. 58.8%) and smokers (78 vs. 45%) than age-matched control patients with NCA. In patients with CAD, the rate of obesity was higher in female group than males (41 vs. 14 %) while the smoking rate was higher than female group (80 vs. 44 %). According to multivariate analysis male sex [Odds ratio (OR) = 7.3, 95% Confidence interval (CI) 4.6- 11.4] and smoking (OR= 2.3, 95% CI 1.6- 3.2) were found to be independent predictors of CAD.Conclusion: We have shown that smoking was the most important risk factor in young adults
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Fatih Aksoy (2019) conducted an observational in Premature coronary artery disease (n=862). Smoking vs. Non-smokers was evaluated on Presence of coronary artery disease (OR 2.30, 95% CI 1.6-3.2, p=<0.001). Smoking was an independent predictor of premature coronary artery disease in adults aged 45 years or younger, increasing the risk with an odds ratio of 2.30.
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