Key result
Low eGFR, low HDL-C, older age, male sex, smoking, high LDL-C, and high lymphocytes were independent risk factors for coronary artery disease in young patients with stable angina pectoris.
Why the study?
The relationship between traditional and nontraditional risk factors and the presence of coronary artery disease in young patients with stable angina pectoris required investigation.
Case-Control (n=571)
In young patients (<60 years) with stable angina pectoris, traditional risk factors like hypertension and diabetes may not reliably predict the presence of significant coronary artery disease, whereas older age, male sex, smoking, lipid profile, and low eGFR are independent predictors.
These factors may aid risk stratification in young stable angina; hypothesis-generating and should not yet change practice.
Background/aim: We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP). Materials and methods: A total of571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD. Results: Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients. Conclusion: Contrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict the presence of CAD in a young population with SAP.
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Duran et al. (2019) conducted a case-control in Stable angina pectoris (n=571). Traditional and nontraditional risk factors vs. Control group with normal coronary angiography was evaluated on Presence of coronary artery disease (at least one-vessel stenosis of ≥70%). Low eGFR, low HDL-C, older age, male sex, smoking, high LDL-C, and high lymphocytes were independent risk factors for coronary artery disease in young patients with stable angina pectoris.
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