Why the study?
Can high-resolution 1H NMR imaging detect regional ischemia in isolated perfused rabbit hearts?
Can high-resolution 1H NMR imaging detect regional ischemia in isolated perfused rabbit hearts?
High-resolution 1H NMR imaging can detect regional ischemia in isolated rabbit hearts via a 28% reduction in T2 relaxation time, potentially reflecting changes in water compartmentalization.
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T2 reduction enables ischemia detection in this rabbit model; leaves open translation to clinical cardiac MRI.
High-resolution 1H NMR images of the isolated perfused rabbit heart were recorded before and after the induction of regional ischemia while the heart was arrested. On T2-weighted images the ischemic region appeared darker than the surrounding tissue and a 28% reduction in T2 was measured from the images. Infusion of an NMR contrast agent demonstrated that the hypointense region on the T2-weighted image was from the ischemic region, which was further confirmed by histological analysis of the heart. It is proposed that the decreased T2 in the ischemic region may be a consequence of changes in water compartmentalization. It is possible that these changes may be used to follow the evolution of tissue injury during ischemia, and therefore provide information regarding the transition between reversible to irreversible injury in the isolated perfused heart.
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Chatham et al. (1991) studied this question.
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