Why the study?
Does DHEA treatment improve right ventricular structure and function in rats with severe pulmonary arterial hypertension?
Population
SU5416/hypoxia/normoxia-exposed rats
Comparison
Dehydroepiandrosterone treatment for 5 weeks vs Untreated SU5416/hypoxia/normoxia-exposed rats
Design
Preclinical
Follow-up
5 weeks
Authors
Loading...
DHEA merits further preclinical study in PAH models; leaves open any role in human right ventricular disease.
Does DHEA treatment improve right ventricular structure and function in rats with severe pulmonary arterial hypertension?
DHEA treatment slows the progression of severe pulmonary arterial hypertension and protects the right ventricle against apoptosis and fibrosis in a rat model, largely through antioxidant activity.
Alzoubi et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: