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June 29, 2005Journal of Biological ChemistryOpen Access

Specific Patterns of Electrophile Adduction Trigger Keap1 Ubiquitination and Nrf2 Activation

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Authors

FHFei HongShaoxing UniversityKSKonjeti R. SekharRoswell Park Comprehensive Cancer CenterMFMichael L. FreemanEastern Health

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Hong et al. (2005) studied this question.

synapsesocial.com/papers/6a2001628fbc0747110db8d6https://doi.org/10.1074/jbc.m503346200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex2004 · 1,265 citations
  2. 2Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers2004 · 987 citations
  3. 3Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.1994 · 1,621 citations
  4. 4Chemoprevention by inducers of carcinogen detoxication enzymes.1997 · 217 citations
  5. 5Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress2003 · 1,480 citations