Key result
Greater carotid intima-media thickness was associated with lower cerebral blood flow in gray matter (β=-1.36; p=0.04), but this became nonsignificant after controlling for cardiovascular risk factors.
Why the study?
It was unknown whether carotid intima-media thickness is associated with measures of cerebral blood flow, white matter hyperintensities, and brain volume in middle-aged individuals.
Is greater carotid intima-media thickness associated with lower cerebral blood flow, white matter hyperintensities, and brain volume in middle-aged individuals?
Population
461 middle-aged individuals in the CARDIA study
Comparison
Composite intima-media thickness across three carotid artery segments
Design
Multicenter population-based cross-sectional cohort study
Authors
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Association may reflect shared cardiovascular risks; leaves open independent effects and needs longitudinal confirmation.
Cross-Sectional (n=461)
Yes
Is greater carotid intima-media thickness associated with lower cerebral blood flow, white matter hyperintensities, and brain volume in middle-aged individuals?
Effect estimate: β=-1.36
p-value: p=0.04
Greater carotid intima-media thickness is associated with lower cerebral blood flow in middle age, an association that appears to be driven by early long-term exposure to traditional cardiovascular risk factors.
Čermáková et al. (2019) conducted a cross-sectional in Atherosclerosis and brain health (n=461). Carotid intima-media thickness was evaluated on Cerebral blood flow (CBF) in gray matter (β=-1.36, p=0.04). Greater carotid intima-media thickness was associated with lower cerebral blood flow in gray matter (β=-1.36; p=0.04), but this became nonsignificant after controlling for cardiovascular risk factors.
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