Key result
A literature review suggests beneficial effects from several classes of medical therapies on diabetic retinopathy, with results from large clinical trials awaited.
Why the study?
Do medical therapies provide beneficial effects in the management of diabetic retinopathy?
Do medical therapies provide beneficial effects in the management of diabetic retinopathy?
Several classes of medical therapies show promise for treating diabetic retinopathy, pending results from large clinical trials.
Medical therapies should not yet change diabetic retinopathy practice; leaves open potential benefits pending large trial confirmation.
Although current treatment and prevention of diabetic retinopathy with laser photocoagulation, and tight metabolic and blood pressure control has reduced the risk of visual loss, there is still a need for additional therapies. A literature review on medical therapies for diabetic retinopathy has been performed, and the following classes of drugs are discussed: blockers of the renin-angiotensin system, protein kinase C-beta inhibitors, glitazones, somatostatin analogues, lipid-lowering drugs and anti-inflammatory drugs. There is experimental and clinical data suggesting beneficial effect from several classes of drugs on diabetic retinopathy, and results from large clinical trials are awaited within the next 3-4 years.
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Sjølie et al. (2004) conducted a review in Diabetic retinopathy. Medical therapies (blockers of the renin-angiotensin system, protein kinase C-beta inhibitors, glitazones, somatostatin analogues, lipid-lowering drugs and anti-inflammatory drugs) was evaluated. A literature review suggests beneficial effects from several classes of medical therapies on diabetic retinopathy, with results from large clinical trials awaited.
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