Secretion of lipoprotein lipase by macrophages in culture.
Key result
Cultured macrophages synthesize and constitutively secrete lipoprotein lipase, a process that is blocked by cycloheximide treatment.
Population
Cultured macrophages
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Macrophage LPL secretion may promote atherogenesis; leaves open in vivo relevance and clinical implications.
Structured PICO
P
Population
Cultured macrophages
I
Intervention
Cycloheximide treatment
O
Outcome
Synthesis and secretion of lipoprotein lipasesurrogate
Cultured macrophages synthesize and secrete lipoprotein lipase, suggesting a potential role for these cells in atherogenesis.
Cite This Study
Khoo et al. (1981) studied this question. Cycloheximide treatment vs. Untreated macrophages was evaluated on Secretion of lipoprotein lipase. Cultured macrophages synthesize and constitutively secrete lipoprotein lipase, a process that is blocked by cycloheximide treatment.