Aquagenic Pruritus: First Manifestation of Polycythemia Vera

Aquagenic Pruritus (AP) can be a first symptom of systemic disease; especially strong correlation with myeloproliferative disorders was described. In Polycythemia Vera (PV) patients its prevalence varies from 31% to 69%. In almost half of the cases AP precedes the diagnosis of PV and has significant influence on sufferers' quality of life. Due to the lack of the insight in pathogenesis of AP the treatment is still largely experiential. However, the new JAK1/2 inhibitors showed promising results in management of AP among PV patients.