Key result
Circulating miR-664a-3p was downregulated in patients with obstructive sleep apnea (with or without increased carotid intima-media thickness) compared to healthy controls.
Why the study?
Does serum miR-664a-3p expression correlate with early atherosclerosis (CIMT) in patients with obstructive sleep apnea?
Population
128 participants divided into 4 groups: 27 healthy volunteers with normal max-CIMT, 31 healthy volunteers…
Comparison
Measurement of serum miR-664a-3p expression vs Healthy volunteers with normal max-CIMT
Design
Cross-sectional
Authors
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Lower miR-664a-3p in OSA irrespective of CIMT suggests limited specificity for atherosclerosis; leaves open biomarker utility pending prospective studies.
Observational (n=128)
Does serum miR-664a-3p expression correlate with early atherosclerosis (CIMT) in patients with obstructive sleep apnea?
Circulating miR-664a-3p is downregulated in patients with obstructive sleep apnea and may serve as a noninvasive biomarker for early atherosclerosis.
Li et al. (2018) conducted an observational in Obstructive sleep apnea and atherosclerosis (n=128). Obstructive sleep apnea and/or increased carotid intima-media thickness vs. Healthy volunteers with normal max-CIMT was evaluated on MiR-664a-3p expression levels and correlation with CIMT. Circulating miR-664a-3p was downregulated in patients with obstructive sleep apnea (with or without increased carotid intima-media thickness) compared to healthy controls.
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