Key result
An experimental human model of intermittent hypoxia identified a restricted signature of exosomal miRNAs and putative endothelial gene target pathways.
Why the study?
Does intermittent hypoxia alter the plasma exosomal micro RNA signature and endothelial function in healthy adults?
Does intermittent hypoxia alter the plasma exosomal micro RNA signature and endothelial function in healthy adults?
Circulating exosomal miRNAs altered by intermittent hypoxia may play a role in cardiovascular dysfunction associated with obstructive sleep apnea by targeting specific effector pathways.
Intermittent hypoxia-induced exosomal miRNA changes are hypothesis-generating; should not yet alter OSA management or endothelial risk assessment.
STUDY OBJECTIVE: Intermittent hypoxia (IH) is associated with increased risk of cardiovascular disease. Exosomes are secreted by most cell types and released in biological fluids, including plasma, and play a role in modifying the functional phenotype of target cells. Using an experimental human model of IH, we investigated potential exosome-derived biomarkers of IH-induced vascular dysfunction. METHODS: ) mRNA expression, ICAM-1 cellular distribution were conducted. RESULTS: expression. Microarray approaches identified a restricted and further validated signature of exosomal miRNAs in D4 exosomes, and mRNA arrays revealed putative endothelial gene target pathways. CONCLUSIONS: . A select number of circulating exosomal miRNAs may play important roles in the cardiovascular dysfunction associated with OSA by targeting specific effector pathways.
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Khalyfa et al. (2016) studied Healthy Adults. Intermittent hypoxia was evaluated on Exosomal miRNA signature and endothelial gene target pathways. An experimental human model of intermittent hypoxia identified a restricted signature of exosomal miRNAs and putative endothelial gene target pathways.
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