Key result
Hepatic lipase deficiency in mice reduced the conversion of intermediate density lipoproteins to low density lipoproteins by 6-fold compared with wild-type mice.
Population
Young hepatic lipase-deficient mice
Comparison
Hepatic lipase deficiency (genetic knockout model) vs Wild-type mice
Design
Preclinical
Authors
Loading...
No immediate implications for human lipid management; leaves open hepatic lipase as a therapeutic target in dyslipidemia.
Effect estimate: 6-fold reduction
Hepatic lipase plays a critical role in the formation of small, dense low density lipoproteins and the normal clearance and processing of chylomicron remnants in mice.
Qiu et al. (1998) studied Hepatic lipase deficiency. Hepatic lipase deficiency vs. Wild-type mice was evaluated on Conversion of intermediate density lipoproteins to low density lipoproteins (6-fold reduction). Hepatic lipase deficiency in mice reduced the conversion of intermediate density lipoproteins to low density lipoproteins by 6-fold compared with wild-type mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: