Key result
Low serum adropin levels (<822 pg/mL) were independently associated with a higher risk of obstructive coronary artery disease (OR 2.71) in patients undergoing invasive coronary angiography.
Why the study?
Adropin is involved in lipid and glucose metabolism and energy homeostasis, but whether it predicts cardiac target organ damage and clinical events in high-risk patients remained unclear.
Does low serum adropin level predict the presence of cardiac target organ damage and clinical events in patients undergoing invasive coronary angiography?
Cross-Sectional (n=344)
No
Does low serum adropin level predict the presence of cardiac target organ damage and clinical events in patients undergoing invasive coronary angiography?
In patients undergoing invasive coronary angiography, low serum adropin levels are independently associated with obstructive CAD, suggesting its potential utility as a diagnostic biomarker.
Answers are grounded in this paper and cite their sources.
Low adropin may aid future risk stratification; hypothesis-generating and should not yet change practice or risk models.
Background and Objectives: Adropin is mainly involved in lipid and glucose metabolism and energy homeostasis.This study was performed to investigate whether adropin could predict the presence of cardiac target organ damage (cTOD) and clinical events in high-risk patients.Methods: A total of 344 consecutive patients with suspected coronary artery disease (CAD) who underwent invasive coronary angiography (ICA; mean age, 64.710.6 years; female, 36.3%) was prospectively analyzed.The Arterial blood samples were obtained immediately before ICA, and serum adropin levels were measured using enzyme-linked immunosorbent assay.During the index admission, 6 cTOD parameters were assessed: CAD, glomerular filtration rate, left ventricular mass index, E/e, brachial-ankle pulse wave velocity and anklebrachial index.Information on major adverse cardiovascular events, including cardiovascular death, non-fatal acute myocardial infarction (AMI), coronary revascularization and stroke, during clinical follow-up was also obtained.Results: Serum adropin could not predict the presence and the number of cTOD.Among 6 cTOD parameters, serum adropin was associated only with CAD.Multivariable analysis showed that low serum adropin (<822 pg/mL) was an independent predictor of obstructive CAD (odds ratio, 2.71; 95% confidence interval, 1.44-5.10;p=0.002).Serum adropin levels decreased in the following order: insignificant CAD, obstructive CAD with angina and obstructive CAD with AMI (p=0.047).Conclusions: Although serum levels of adropin were not associated with cTODs, they were associated with CAD in patients undergoing ICA.This result provides additional evidence on the role of adropin in CAD diagnosis.
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Kim et al. (2023) conducted a cross-sectional in Suspected coronary artery disease (n=344). Low serum adropin level (<822 pg/mL) vs. Higher serum adropin level (≥822 pg/mL) was evaluated on Obstructive coronary artery disease (OR 2.71, 95% CI 1.44-5.10, p=0.002). Low serum adropin levels (<822 pg/mL) were independently associated with a higher risk of obstructive coronary artery disease (OR 2.71) in patients undergoing invasive coronary angiography.
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