Key result
Deletion of sequences 5' to the s gamma 1 region in mice abolished recombination to this switch region, resulting in selective agammaglobulinemia.
Deletion of 5' switch region flanking sequences abolishes class switch recombination to the s gamma 1 region, demonstrating their functional importance in vivo.
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Establishes in vivo role of 5' sequences in class switching in mice; leaves open relevance to human B-cell disorders.
Jung et al. (1993) studied Selective agammaglobulinemia. Deletion of sequences 5' to the s gamma 1 region was evaluated on Recombination to the s gamma 1 switch region. Deletion of sequences 5' to the s gamma 1 region in mice abolished recombination to this switch region, resulting in selective agammaglobulinemia.
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