Population
Rat hearts
Comparison
Complete global ischemia and anoxia for 30 or 60… vs Hearts incubated in cold saline and nonincubated…
Design
Preclinical
Authors
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No clinical implications from rat ischemia model; leaves open troponin effects on human Ca2+ regulation.
Complete global ischemia in rat hearts leads to degradation of troponin I and T, which may contribute to altered cooperativity of Ca2+ regulation of ATPase activity.
Westfall et al. (1992) studied this question.
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