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January 23, 2019Science Translational Medicine

Cyclin G1 and TASCC regulate kidney epithelial cell G ₂ -M arrest and fibrotic maladaptive repair

Guillaume Canaud Craig R. Brooks Seiji Kishi Kensei Taguchi Kenji Nishimura Sato Magassa Adam Scott Li‐Li Hsiao Takaharu Ichimura Fabiola Terzi Li Yang Joseph V. Bonventre

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Abstract

Cyclin G1 regulates G 2 -M arrest in proximal tubular cells, promoting a TASCC-induced secretory phenotype, fibrosis, and kidney disease progression.

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Canaud et al. (2019) studied this question.

synapsesocial.com/papers/6a200738d5e8712fdf65b4a1 https://doi.org/10.1126/scitranslmed.aav4754

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term functionOriginal Research · 2001 · 404 citations
2Yes, AKI Truly Leads to CKDMeta-Analysis · 2012 · 155 citations
3Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationCohort Study · 2004 · 11,378 citations
4Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidneyOriginal Research · 1998 · 155 citations
5Cellular pathophysiology of ischemic acute kidney injuryReview · 2011 · 2,020 citations

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