Key result
Dysregulation of adipose tissue expandability and abnormal adipokine production are key mechanisms underlying obesity-associated metabolic dysregulation and insulin resistance.
Understanding adipose tissue plasticity and expandability provides a molecular basis for obesity-associated insulin resistance and highlights potential therapeutic strategies for managing metabolic syndrome.
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Hypothesis-generating for adipose-targeted therapies in metabolic syndrome; leaves open prospective trials to assess clinical efficacy.
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Sethi et al. (2007) conducted a review in Obesity and metabolic syndrome. Adipose tissue expandability and adipokine production was evaluated. Dysregulation of adipose tissue expandability and abnormal adipokine production are key mechanisms underlying obesity-associated metabolic dysregulation and insulin resistance.
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