Key result
Respiratory cardiac cycle variability is closely related to respiratory systolic blood pressure variability, with the phase difference reflecting the effect of the pulmonary stretch reflex dependent on respiratory period.
Respiratory cardiac cycle variability is closely related to systolic blood pressure variability, but their phase difference depends on the respiratory period, likely reflecting pulmonary stretch reflex effects.
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May refine cardiorespiratory coupling models; leaves open clinical relevance for variability-based risk assessment.
This study was undertaken to clarify the influence of respiratory blood pressure variability upon the relationship between respiratory period and respiratory cardiac cycle variability. In 4 healthy male university students respiratory period was varied over the range of 6-20 sec while tidal volume was maintained constant (21) and in 5 other male students tidal volume was varied over the range of 1.0-2.5l while respiratory period was maintained constant (6 sec) . For cardiac cycle (RR) and systolic and diastolic blood pressure (SBP and DBP), amplitude of respiratory variability and phase difference between respiratory variability and respiration were measured.1. Patterns of change of amplitude of RR and of SBP were similar when respiratory period was changed.2. When respiratory period was short (6sec), RR was nearly in phase with SBP. However, as respiratory period increased, the phases of RR and SBP had a tendency to proceed, with the tendency being more pronounced in the latter. Thus, when respiratory period was prolonged (20 sec), SBP led RR.3. Phase relationship between respiratory SBP variability and respiration did not change when tidal volume was changed.4. Respiratory DBP variability became more marked as respiratory period increased, and showed more marked phase shift than did respiratory SBP variability. Therefore, of those parameters DBP occurred earlier.Based on these results, it is concluded that respiratory RR variability is closely related to respiratory SBP variability when respiratory period is changed, but that the phase difference between RR and SBP reflects the effect of pulmonary stretch reflex which is dependent on respiratory period.
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Sone et al. (1992) studied Healthy (n=9). Controlled changes in respiratory period and tidal volume vs. Constant respiratory period or tidal volume was evaluated on Phase difference and amplitude of respiratory variability for cardiac cycle (RR) and blood pressure (SBP and DBP). Respiratory cardiac cycle variability is closely related to respiratory systolic blood pressure variability, with the phase difference reflecting the effect of the pulmonary stretch reflex dependent on respiratory period.
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