January 1, 1990Clinical and Experimental Pharmacology and Physiology
Effects of Neuropeptide Y on Baroreflex Control of Heart Rate and Myocardial Contractility in Conscious Rabbits
Key result
Intravenous neuropeptide Y increased the maximum slope of the MAP-HP curve from 7.0 to 10.6 ms/mmHg (P<0.05) in conscious rabbits, indicating an effect on baroreflex control.
Population
Conscious, normotensive rabbits
Design
Preclinical
Follow-up
5-15 minutes post-administration
Authors
Discussion
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Implication
Animal findings on baroreflex modulation do not inform practice; leaves open NPY relevance in human cardiovascular control.
Structured PICO
P
Population
Conscious, normotensive rabbits evaluated for the effects of neuropeptide Y on baroreflex control.
I
Intervention
Intravenous neuropeptide Y (NPY, 10 micrograms/kg bolus)
O
Outcome
Stimulus-response curves relating changes in heart period (HP) and in peak left ventricular (LV) dP/dt to acute changes in mean arterial pressure (MAP)surrogate
Main Result
Absolute Event Rate: 10.6% vs 7%
p-value: p=<0.05
Neuropeptide Y modulates baroreflex control of heart rate and myocardial contractility in conscious rabbits, likely through a reduction in cardiac beta-adrenergic tone.
Cite This Study
Minson et al. (1990) studied conscious, normotensive rabbits. Neuropeptide Y (NPY) was evaluated on maximum slope (sensitivity) at the midpoint of the MAP-HP curve (p=<0.05). Intravenous neuropeptide Y increased the maximum slope of the MAP-HP curve from 7.0 to 10.6 ms/mmHg (P<0.05) in conscious rabbits, indicating an effect on baroreflex control.