March 10, 2025Neuron11 citationsOpen Access

Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males

JHJessica A. Higginbotham JAJulian G. Abt RTRachel H. Teich

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Abstract

activity through VTA estrogen receptor beta signaling. These findings highlight the importance of assessing hormonal factors in opioid misuse liability in the context of pain.

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Higginbotham et al. (Mon,) studied this question.

synapsesocial.com/papers/6a200c8b7110a651dc04eae8 https://doi.org/https://doi.org/10.1016/j.neuron.2025.02.013

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