Key result
Acute hyperinsulinemia decreased R-R interval (P<0.001) and increased muscle sympathetic nerve activity >2-fold (P<0.001), indicating cardiac vagal withdrawal and nonuniform sympathetic activation.
Why the study?
Does acute physiological hyperinsulinemia alter autonomic control (RRI and MSNA) in normal subjects?
Population
16 normal subjects
Design
Other
Follow-up
90 minutes
Authors
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May underlie tachycardia via autonomic effects in healthy subjects; leaves open relevance to insulin-resistant states.
Does acute physiological hyperinsulinemia alter autonomic control (RRI and MSNA) in normal subjects?
p-value: p=<0.001
Acute hyperinsulinemia reduces cardiac vagal tone and causes regionally nonuniform increases in sympathetic activity, contributing to tachycardia.
Borne et al. (1999) studied Normal subjects (n=16). Hyperinsulinemic/euglycemic clamp was evaluated on R-R interval (RRI) and muscle sympathetic nerve activity (MSNA) (p=<0.001). Acute hyperinsulinemia decreased R-R interval (P<0.001) and increased muscle sympathetic nerve activity >2-fold (P<0.001), indicating cardiac vagal withdrawal and nonuniform sympathetic activation.
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