Key result
In critically ill stroke patients, low mean arterial pressure (≤ 70 mmHg) significantly increased 7-day and 28-day mortality compared to normal MAP (p < 0.05), while high MAP did not.
Why the study?
Abnormal blood pressure is common in critically ill stroke patients, but the association between mean arterial pressure and mortality remains unclear.
Does mean arterial pressure during the first 24 hours affect 7-day and 28-day mortality in critically ill stroke patients?
Population
2885 acute stroke patients from the MIMIC-III database
Comparison
Low MAP (≤ 70 mmHg) vs normal MAP (70 to ≤ 90 mmHg) vs high MAP (> 90 mmHg)
Design
Retrospective database analysis
Follow-up
28 days
Authors
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Avoiding low MAP may merit attention in stroke ICU care; hypothesis-generating for MAP targets in prospective trials.
Observational (n=2,885)
Does mean arterial pressure during the first 24 hours affect 7-day and 28-day mortality in critically ill stroke patients?
p-value: p=< 0.05
In critically ill stroke patients, a low mean arterial pressure (≤ 70 mmHg) during the first 24 hours is associated with increased short-term mortality, whereas a high MAP is not, suggesting that avoiding hypotension may be more critical than treating hypertension in this acute setting.
Zhang et al. (2023) conducted an observational in critically ill stroke (n=2,885). Low mean arterial pressure (MAP ≤ 70 mmHg) vs. Normal MAP (70 mmHg < MAP ≤ 90 mmHg) was evaluated on 7-day and 28-day mortality (p=< 0.05). In critically ill stroke patients, low mean arterial pressure (≤ 70 mmHg) significantly increased 7-day and 28-day mortality compared to normal MAP (p < 0.05), while high MAP did not.
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