Key result
Noninvasive EF estimation via left ventricular arterial coupling correlates with echocardiography with ~24% error.
Why the study?
It is impossible to continuously and non-invasively assess ejection fraction using ultrasonography.
Does non-invasive estimation of ejection fraction using left ventricular arterial coupling agree with transthoracic echocardiography in healthy adults?
Observational (n=44)
No
Does non-invasive estimation of ejection fraction using left ventricular arterial coupling agree with transthoracic echocardiography in healthy adults?
Effect estimate: bias 8.5% (95% CI -7.5 to 24.4)
Absolute Event Rate: 57% vs 66%
p-value: p=<0.05
Non-invasive estimation of ejection fraction using left ventricular arterial coupling showed clinically acceptable agreement with echocardiography in healthy adults, offering a potential method for continuous monitoring.
BACKGROUND: Ejection fraction (EF), which is assessed using ultrasonography, is a standard parameter for evaluating cardiac function in clinical cardiology and for cardiovascular management during general anesthesia. However, it is impossible to continuously and non-invasively assess EF using ultrasonography. The aim of our study was to develop a method for estimating EF non-invasively using the left ventricular arterial coupling ratio (Ees/Ea). METHODS: Ees/Ea was estimated non-invasively using the parameters pre-ejection period (PEP), ejection time (ET), end-systolic pressure (Pes) and diastolic pressure (Pad), which were calculated from a vascular screening system, VeSera 1000/1500 (Fukuda Denshi Co., Ltd., Tokyo, Japan). Then, left ventricular efficiency (Eff) as a pump, defined as the ratio of external work (EW) to myocardial oxygen consumption, which strongly correlates with the pressure-volume area (PVA), was calculated by a new formula using Ees/Ea, and was used to approximate EF (EFeff). Simultaneously, we measured EF using transthoracic echocardiography (EFecho), and compared it with EFeff. RESULTS: = 0.219, p < 0.05) on Bland-Altman analysis, with limits of agreement of - 7.5 to 24.4%, and percentage error of 24%. CONCLUSION: The results suggest that EF can be measured non-invasively using left ventricular arterial coupling.
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Yamazaki et al. (2023) conducted an observational in Healthy adults (n=44). Noninvasive estimation of ejection fraction (EFeff) using left ventricular arterial coupling vs. Transthoracic echocardiography (EFecho) was evaluated on Agreement between EFeff and EFecho (bias 8.5%, 95% CI -7.5 to 24.4, p=<0.05). Noninvasive estimation of ejection fraction using left ventricular arterial coupling showed a positive correlation with echocardiography (R2 = 0.219, p < 0.05) with a bias of 8.5% and a clinically acceptable percentage error of 24%.
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