July 12, 2021Expert Review of Cardiovascular Therapy
Ventricular-arterial coupling: definition, pathophysiology and therapeutic targets in cardiovascular disease
Key result
Newer methods such as the PWV/GLS-ratio may be superior markers of ventricular-arterial coupling than traditional echocardiographic Ea/Ees in predicting target organ damage and clinical outcomes.
Why the study?
The concept of ventricular-arterial coupling (VAC) is evolving beyond traditional echocardiographic measures to newer methods, alongside growing understanding of how cardio-metabolic risk factors and therapies affect VAC.
How is ventricular-arterial coupling defined, assessed, and targeted therapeutically in cardiovascular disease?
Design
Narrative review based on a systematic PubMed search
Authors
Discussion
Loading...
Member takes
Implication
May support PWV/GLS-ratio validation in VAC research; leaves open clinical adoption or therapeutic targeting.
Structured PICO
How is ventricular-arterial coupling defined, assessed, and targeted therapeutically in cardiovascular disease?
P
Population
Patients with cardiovascular disease and cardio-metabolic risk factors
E
Exposure
Therapeutic interventions to normalize ventricular-arterial coupling (e.g., novel anti-diabetic drugs, optimal antihypertensive treatment)
O
Outcome
Assessment of ventricular-arterial coupling (VAC) and its association with clinical outcomes and target organ damage
Novel methods like the PWV/GLS-ratio may offer superior assessment of ventricular-arterial coupling compared to traditional echocardiography, highlighting VAC as a potential therapeutic target using anti-diabetic and antihypertensive drugs.
Cite This Study
Saeed et al. (2021) conducted a review in Cardiovascular disease. Ventricular-arterial coupling assessment was evaluated. Newer methods such as the PWV/GLS-ratio may be superior markers of ventricular-arterial coupling than traditional echocardiographic Ea/Ees in predicting target organ damage and clinical outcomes.