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February 1, 1996Obstetrics and Gynecology

Cardiac output in normal pregnancy: A critical review

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Key result

Normal pregnancy increased cardiac output early in the first trimester and further in the second, with widely divergent changes in the third trimester dependent on individual factors.

Why the study?

How does cardiac output change throughout the course of a normal pregnancy?

Population

Women with normal pregnancy

Comparison

Progression of normal pregnancy vs Different trimesters and postpartum period

Design

Systematic_review

Follow-up

Throughout pregnancy and postpartum

Authors

AVA VANOPPENUtrecht UniversityRSR. H. StigterDeventer ZiekenhuisHBH BRUINSEUniversity Medical Center Utrecht

Discussion

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Member takes

Overview

Informs personalized hemodynamic monitoring in late pregnancy; reinforces consensus on early rises with high individual variability.

Structured PICO

How does cardiac output change throughout the course of a normal pregnancy?

P
Population
A review of 6 definitive longitudinal studies and 33 cross-sectional studies assessing the effect of normal pregnancy on cardiac output.
E
Exposure
Progression of normal pregnancy
C
Comparator
Different trimesters and postpartum period
O
Outcome
Cardiac outputsurrogate

Cardiac output increases during the first and second trimesters of normal pregnancy, but third-trimester changes are highly variable among individuals.

Limitations

  • The tendency to report cardiac output as averages negated inter-individual differences.
  • Averaging negates inter-individual differences in the third trimester

Cite This Study

VANOPPEN et al. (1996) conducted a review in Normal pregnancy. Normal pregnancy vs. Different trimesters and postpartum was evaluated on Cardiac output. Normal pregnancy increased cardiac output early in the first trimester and further in the second, with widely divergent changes in the third trimester dependent on individual factors.

synapsesocial.com/papers/6a2011e117bd4d7ccf04d239https://doi.org/10.1016/0029-7844(95)00348-7
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic peptide concentrations and hemodynamic effects of acute plasma volume expansion in normal pregnancy and preeclampsia1993 · 28 citations
  2. 2Methodological Guidelines for Impedance Cardiography1990 · 1,190 citations