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This research aims to determine whether murine natural killer cells express functional transcripts of T cell receptor genes.

Murine natural killer cells do not express functional transcripts of the alpha-, beta-, or gamma-chain genes of the T cell receptor.

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This research aims to determine whether murine natural killer cells express functional transcripts of T cell receptor genes.
Murine NK cells were purified using anti-NK-1.1 antibodies.
NK-1.1+ cells were propagated in human recombinant IL 2 for 3 to 4 weeks.
Northern blot analysis was employed to probe for T cell receptor gene transcripts.
No functional transcripts of the alpha-, beta-, or gamma-chain genes of the T cell receptor were detected.
These findings separate natural killer cells from mature cytotoxic T cells.
NK cell characteristics remained consistent with fresh splenic NK cells throughout the cultivation.

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Randomized trial uncovers lack of T cell receptor gene transcripts in murine NK cells, suggesting functional differences.

Tutt et al. (1986) studied this question.

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