Key result
Celecoxib did not significantly alter the antiplatelet activity of aspirin compared to placebo, with similar thromboxane inhibition (99.0% vs 99.4%; p=0.555).
Why the study?
Does celecoxib alter the antiplatelet effect of aspirin in healthy volunteers?
RCT (n=16)
Double-blind
Does celecoxib alter the antiplatelet effect of aspirin in healthy volunteers?
Absolute Event Rate: 99% vs 99.4%
p-value: p=0.555
Celecoxib does not interfere with the antiplatelet activity of aspirin, suggesting they can be co-administered without compromising aspirin's cardiovascular protective effects.
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Supports co-administration of celecoxib with aspirin without compromising antiplatelet effects; confirms no interaction in this RCT.
Wilner et al. (2002) conducted an RCT in Healthy volunteers (n=16). Celecoxib vs. Placebo was evaluated on Thromboxane inhibition (p=0.555). Celecoxib did not significantly alter the antiplatelet activity of aspirin compared to placebo, with similar thromboxane inhibition (99.0% vs 99.4%; p=0.555).
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