Key result
In 50 middle-aged patients with type 2 diabetes, elevated serum homocysteine levels were associated with the presence of cardiovascular complications.
Why the study?
Are elevated serum homocysteine levels associated with cardiovascular complications in middle-aged patients with type 2 diabetes mellitus?
Cross-Sectional (n=50)
Yes
Are elevated serum homocysteine levels associated with cardiovascular complications in middle-aged patients with type 2 diabetes mellitus?
Hyperhomocysteinaemia is identified as a potential independent risk factor for cardiovascular disease incidence in middle-aged patients with type 2 diabetes.
No immediate practice change indicated; leaves open causal role and need for prospective trials in diabetes.
BACKGROUND mellitus (DM) is a syndrome characterized by chronic hyperglycaemia and disturbances of carbohydrate, fat, and metabolism associated with absolute or relative deficiencies in insulin secretion and/or insulin action. Worldwide, 200 million people currently have type II diabetes mellitus (DM), a prevalence that has been predicted to increase 366 million by 2030. AND METHODS participants are selected from those who visited Diabetes Clinic, in Al-Ameen Medical College Hospital and District Hospital, between Dec 2013 - June 2015. 50 patients presenting with type 2 diabetes mellitus in middle age are included in the . In our study, diabetic patients with cardiovascular complications had poor glycaemic status compared to diabetic patient cardiovascular complications. results of this study confirm the hypothesis that hyperhomocysteinaemia is a risk factor for endothelial dysfunction and diseases such as atherosclerosis and occlusive vascular disorders. homocysteine levels were comparatively more elevated in patients of diabetes with cardiovascular complications than the of diabetes alone, thus indicating that hyperhomocysteinaemia is an independent risk factor for CVD incidence in type 2 diabetic patients in middle age individuals.
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Abdullah et al. (2018) conducted a cross-sectional in Type 2 diabetes mellitus (n=50). Elevated serum homocysteine levels vs. Normal homocysteine levels was evaluated on Cardiovascular complications. In 50 middle-aged patients with type 2 diabetes, elevated serum homocysteine levels were associated with the presence of cardiovascular complications.
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