Key result
Novel variable loop PFA catheter achieves 100% acute PVI with no periprocedural complications.
Why the study?
A novel multielectrode variable loop catheter has been introduced for AF ablation enabling 3D electroanatomic mapping and concomitant pulsed field ablation, but required investigation under routine clinical conditions.
Does pulsed field ablation using a novel variable loop catheter achieve acute pulmonary vein isolation safely in patients with symptomatic atrial fibrillation?
Observational (n=45)
No
Does pulsed field ablation using a novel variable loop catheter achieve acute pulmonary vein isolation safely in patients with symptomatic atrial fibrillation?
The novel variable loop catheter is safe and effective for achieving acute pulmonary vein isolation and allows for adequate 3D electroanatomic mapping during pulsed field ablation procedures.
Supports feasibility of novel variable loop catheter for pulsed field ablation; leaves open durability, comparative efficacy, and need for randomized trials.
BACKGROUND AND AIMS: A novel multielectrode variable loop catheter (VLC) has been introduced for atrial fibrillation (AF) ablation enabling 3D electroanatomic mapping and concomitant pulsed field ablation (PFA). This study sought to investigate the VLC under routine clinical conditions for AF ablation. METHODS: Consecutive patients with symptomatic AF undergoing first-time AF ablation were prospectively enrolled. All procedures were carried out using the VLC. Electroanatomic mapping pre and post-ablation was conducted with the VLC and a high-density multipolar mapping catheter. The general ablation protocol consisted of four ablation pulses per pulmonary vein (PV). All procedures were conducted in conscious sedation. RESULTS: Forty-five patients (mean age 66.3 ± 6.1 years, 68.9% paroxysmal AF) were analyzed. Procedure duration was 66.3 ± 13.1 min. Acute pulmonary vein isolation (PVI) was achieved in 45 patients without periprocedural complications. Remapping after the initial 16 ablation pulses revealed sustained electrical conduction to at least one PV in six patients (13.3%). Repeat ablation was conducted and with an average of 7.5 ± 4.5 additional pulses. PV intubation during mapping was achieved in 168/180 PVs with the VLC (93.3%) and in 180/180PVs (100%) with the high-density mapping catheter (p < 0.001). Incomplete PV intubation during mapping did not result in incomplete PVI, as demonstrated by remapping utilizing the high-density mapping catheter. Adequate correlation between left atrial post-ablation remapping of low voltage areas and ablated regions was demonstrated in all patients. CONCLUSION: PFA-guided AF ablation using the novel VLC is safe and effective. The integration into a 3D-electroanatomic mapping system enables adequate mapping during PFA procedures.
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Fink et al. (2025) conducted an observational in Atrial Fibrillation (n=45). Variable loop catheter (VLC) was evaluated on Acute pulmonary vein isolation (PVI). Pulsed field ablation using the novel variable loop catheter achieved acute pulmonary vein isolation in 100% of patients without any periprocedural complications.
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