Oral administration of disopyramide completely suppressed ventricular fibrillation storms in a patient with Brugada syndrome, with recurrence upon discontinuation and suppression upon restart.
Case Report (n=1)
Does oral disopyramide prevent ventricular fibrillation storms in a patient with Brugada syndrome?
Oral disopyramide may be highly effective in suppressing ventricular fibrillation storms in patients with Brugada syndrome.
The patient was a 57-year-old man with Brugada syndrome, who had been implanted with a implantable cardioverter defibrillator (ICD). The frequency of ventricular fibrillation (VF) started to increase about 4 years after ICD implantation, occurring, at worst, six times in one night. Immediately after starting oral administration of disopyramide, VF stopped occurring. He then discontinued taking disopyramide, but immediately after the discontinuation VF started occurring again, so he restarted taking disopyramide. Thereafter, VF completely stopped occurring. Findings observed in our case suggest that disopyramide could be added in our arsenal of medications for treating arrhythmic storms in patient with Brugada syndrome.
Sumi et al. (Mon,) conducted a case report in Brugada syndrome with ventricular fibrillation storms (n=1). Disopyramide vs. Off-drug periods was evaluated on Occurrence of ventricular fibrillation. Oral administration of disopyramide completely suppressed ventricular fibrillation storms in a patient with Brugada syndrome, with recurrence upon discontinuation and suppression upon restart.