Key result
The renin-angiotensin system, particularly angiotensin II acting via the AT1 receptor, plays a role in normal breast function and may increase tumor cell proliferation and angiogenesis in breast cancer.
This review highlights the presence and functional role of a local renin-angiotensin system in the breast, suggesting that its dysregulation in breast cancer could make it a potential therapeutic target.
No takes yet. Share an insight, caveat, or question.
May support AT1 blockade as a therapeutic target in breast cancer; leaves open need for clinical trials to confirm benefit.
Vinson et al. (2011) conducted a review in Breast cancer. Renin-angiotensin system inhibitors was evaluated. The renin-angiotensin system, particularly angiotensin II acting via the AT1 receptor, plays a role in normal breast function and may increase tumor cell proliferation and angiogenesis in breast cancer.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: