Key result
In cardiomyopathic hamsters, combined enalapril and spironolactone did not improve hemodynamics more than enalapril alone but induced stronger effects on cardiac remodeling.
Why the study?
Does the combination of enalapril and spironolactone improve hemodynamics and cardiac remodeling compared to either drug alone or no treatment in cardiomyopathic hamsters?
Does the combination of enalapril and spironolactone improve hemodynamics and cardiac remodeling compared to either drug alone or no treatment in cardiomyopathic hamsters?
In a hamster model of dilated cardiomyopathy, combining enalapril and spironolactone provided additive benefits on cardiac remodeling but not hemodynamics compared to monotherapy.
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Hypothesis-generating for remodeling benefits in cardiomyopathy models; leaves open translation to human HF management.
Goineau et al. (2003) studied Dilated cardiomyopathy (n=104). Enalapril and spironolactone vs. Untreated control, enalapril alone, spironolactone alone was evaluated on Hemodynamics and cardiac remodeling. In cardiomyopathic hamsters, combined enalapril and spironolactone did not improve hemodynamics more than enalapril alone but induced stronger effects on cardiac remodeling.
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