Key result
Bradykinin increased glucose uptake and oxidation in isolated perfused rat hearts indirectly by enhancing nutritional flow, but had no direct effect on glucose transport in isolated cardiac myocytes.
Why the study?
Does bradykinin influence myocardial glucose metabolism in isolated cardiac myocytes and perfused rat hearts?
Population
Isolated cardiac myocytes and isolated perfused rat hearts (including diabetic hearts)
Comparison
Bradykinin (with or without insulin) vs Control (no bradykinin) or insulin alone
Design
Preclinical
Authors
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These rat heart findings should not change clinical metabolic practice; leaves open translation to human myocardium.
Does bradykinin influence myocardial glucose metabolism in isolated cardiac myocytes and perfused rat hearts?
Bradykinin indirectly accelerates glucose metabolism in the isolated perfused heart, likely by enhancing nutritional flow across the capillary wall, rather than directly affecting glucose transport.
Rösen et al. (1983) studied Isolated cardiac myocytes and isolated perfused rat hearts. Bradykinin vs. Control / Insulin alone was evaluated on Myocardial glucose transport, uptake, and oxidation. Bradykinin increased glucose uptake and oxidation in isolated perfused rat hearts indirectly by enhancing nutritional flow, but had no direct effect on glucose transport in isolated cardiac myocytes.
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