Key result
A review of published results indicates no evidence that angiotensin II directly triggers mitogenesis through the cyclin-dependent pathway in cardiac fibroblasts.
Why the study?
Does angiotensin II directly stimulate proliferation in cardiac fibroblasts?
Does angiotensin II directly stimulate proliferation in cardiac fibroblasts?
Angiotensin II likely promotes cardiac fibroblast proliferation indirectly by stimulating the synthesis of growth factors and cytokines rather than through direct mitogenesis.
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No direct cyclin-dependent mitogenesis by angiotensin II in fibroblasts; leaves open indirect growth factor mechanisms for targeted study.
F Bouzegrhane (2002) conducted a review in Cardiac remodeling and left ventricular hypertrophy. Angiotensin II was evaluated on Mitogenesis and proliferation of cardiac fibroblasts. A review of published results indicates no evidence that angiotensin II directly triggers mitogenesis through the cyclin-dependent pathway in cardiac fibroblasts.
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